Original Research Article
Comparison of the Automatic Non-invasive Express Screening Analyser (ANESA)® for Clinical Analytical Parameters
Antoni Sicras-Mainar1* and Luis Collado-Yurrita2
1Investigation Unit, Badalona Serveis Assistencials SA, Badalona, Barcelona, Spain.
2Department of Medicine, Faculty of Medicine, Complutense University of Madrid, Spain.
Abstracts
Background:
The objective we evaluated the reliability of some haematological and
biochemical parameters performed by a non-invasive auto-analyser (ANESA)
with those obtained by the standard method of venipuncture (reference
method) in patients who went to the clinical analysis laboratory
(Municipal-Hospital of Badalona, Spain).
Methods: A transversal,
comparative and parallel (paired) study was carried out. Two methods of
study were practiced for the same subject: a) the reference method of
venipuncture (conventional clinical analysis) and b) placement of
sensors (comparison method: ANESA device). Consecutive patients older
than 18 years, who met certain criteria for inclusion were included in
the study during an 8 week period in 2014. The parameters studied were:
haemogram (7), glucose, lipids (4), transaminases (2), bilirubin,
creatinine and urea. Statistical analysis compared averages for paired
groups and reliability of the obtained observations (method:
intraclass-correlation coefficient (ICC); individual differences:
Bland–Altman method), p<0.05.
Results: A total of 195
patients were involved, with an average age of 50.8 years; 65.2% were
women. In paired comparisons, cholesterol (185.4 vs. 179.8; difference:
5.6 mg/dL; p=0.005), cLDL (95.9 vs. 100.5; difference: −4.6 mg/dL;
p=0.002) and bilirubin (0.6 vs. 0.5; difference: 0.1 mg/dL; p<0.001)
obtained more modest results. Erythrocytes, haemoglobin, haematocrit,
platelets, leukocytes, glucose, cHDL, triglycerides, ALT, AST,
creatinine and urea reached an ICC>0.90. Lipid parameters
(cholesterol: ICC=0.728; cLDL: ICC=0.817) obtained a moderate
correlation, whereas lymphocytes (ICC=0.551) and monocytes (ICC=0.546)
reached discrete results.
Conclusions: Despite of
the study limitations, the automatic non-invasive analyser (ANESA) is
shown as a reliable and promising screening method in usual clinical
practice for most of the analyzed parameters as an alternative to
standard blood extraction. However, more studies are required to
strengthen the consistency of the results.
Keywords :
Reliability; non-invasive analyser; clinical analysis.
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